Maximizing Your GLP-1 Results: The Supplements That Support Weight Loss and Wellness
If you read our first blog, “GLP-1 Medications: Why They’re a Powerful Tool — But Not a “Set It and Forget It” Solution” you know that GLP-1 medications like semaglutide and tirzepatide are powerful tools for weight management — but they’re not a “set it and forget it” solution. To get the most from your therapy, the right supplementation strategy can make a huge difference.
At Restore Compounding Pharmacy in Tampa, we help patients integrate evidence-based supplements alongside GLP-1 therapy to improve fat loss, maintain lean muscle, and enhance overall wellness.
1. Protein Powders: Preserve Muscle, Support Satiety
Even with appetite suppression from GLP-1s, your body still needs adequate protein to preserve muscle during weight loss.
Whey protein is fast-absorbing and ideal post-workout
Plant-based proteins (pea, rice, hemp) are excellent for those with dietary restrictions
Target: 0.8–1 gram of protein per pound of body weight daily
Protein powders make it easier to hit your daily goals, even when your appetite is naturally lower.
2. Creatine: Strength and Muscle Preservation
Creatine is a proven supplement for muscle retention and performance — critical when losing weight on GLP-1 therapy.
Improves strength during resistance training
Supports lean muscle mass while reducing fat
May enhance cognitive performance and energy
Adding 5-10g grams per day can help maintain strength and physical function as you lose weight.
3. Omega-3 Fatty Acids: Anti-Inflammatory Support
GLP-1 therapy can enhance metabolic health, but chronic inflammation can hinder results. Omega-3 fatty acids:
Support heart health and insulin sensitivity
Reduce inflammation in muscles and joints
Improve overall wellness
A high-quality fish oil or algae-based omega-3 supplement can complement your weight loss and metabolic goals.
4. Vitamin D: Optimizing Hormones and Energy
Low vitamin D levels are common and can interfere with:
Hormone balance
Muscle function
Energy and mood
Correcting deficiency through supplementation can support weight loss, muscle recovery, and metabolic health while on GLP-1 therapy.
5. Magnesium: Muscle Recovery and Blood Sugar Support
Magnesium plays a key role in blood sugar regulation, muscle relaxation, and energy metabolism. Supplements can help:
Reduce muscle cramps after workouts
Support glucose control
Improve sleep quality, which aids weight loss
6. Collagen Peptides: Skin, Joints, and Recovery
While GLP-1 supports fat loss, collagen peptides can help:
Maintain skin elasticity during weight changes
Support joint health for resistance training
Improve gut and connective tissue health
Putting It All Together
GLP-1 medications are incredibly effective, but combining therapy with the right supplements ensures:
Fat loss while maintaining lean muscle
Enhanced energy and exercise performance
Improved metabolic health and recovery
At Restore Compounding Pharmacy, we can guide patients on the optimal supplement stack for their GLP-1 regimen — including protein, creatine, omega-3s, vitamins, and more — to make your results faster, safer, and more sustainable.
Are you in the Tampa Bay area and looking to maximize your medically supervised weight loss results? Contact Restore Pharmacy to learn about our pharmacist-led guidance, sublingual GLP-1 formulations, and personalized supplement recommendations.
